| 01/05/2026 04:00 | | Union Cocle Reserves  | 3 - 0 | San Francisco Reserves | B |
| 25/04/2026 08:00 | | San Francisco Reserves | 3 - 1 | SD Atletico Nacional | T |
| 11/04/2026 08:00 | | San Francisco Reserves | 1 - 3 | Aguilas UP | B |
| 05/04/2026 21:00 | | Udelas FC | 2 - 0 | San Francisco Reserves | B |
| 28/03/2026 08:00 | | San Francisco Reserves | 0 - 1 | CD Universitario Reserves | B |
| 14/03/2026 04:00 | | San Francisco Reserves | 3 - 1 | CD Bocas Junior | T |
| 05/03/2026 08:00 | | La Familia FC | 0 - 1 | San Francisco Reserves | T |
| 28/02/2026 08:00 | | San Francisco Reserves | 1 - 1 | Veraguas FC Reserves | H |
| 11/02/2026 08:00 | | San Francisco Reserves | 1 - 1 | CA Independiente de la Chorrera Reserves | H |
| 06/02/2026 08:00 | | SD Atletico Nacional Reserves | 2 - 0 | San Francisco Reserves | B |
Panama