| 25/06/2026 21:00 | | General Lamadrid Reserves  | 1 - 0 | CA Lugano Reserves | B |
| 09/06/2026 23:00 | | CA Lugano Reserves | 1 - 1 | Leones de Rosario Reserve | H |
| 02/06/2026 20:10 | | El Porvenir Reserves | 0 - 0 | CA Lugano Reserves | H |
| 26/05/2026 21:10 | | CA Lugano Reserves | 3 - 0 | Victoriano Arenas Reserves | T |
| 21/05/2026 21:10 | | Yupanqui Reserves | 2 - 0 | CA Lugano Reserves | B |
| 05/05/2026 21:00 | | CA Lugano Reserves | 1 - 0 | Canuelas FC Reserves | T |
| 30/04/2026 23:00 | | Sacachispas Reserves | 1 - 6 | CA Lugano Reserves | T |
| 21/04/2026 22:00 | | CA Lugano Reserves | 0 - 1 | Estrella del Sur Reserves | B |
Argentina